2014.6/13-17 The American Diabetes Association 74nd Scientific Sessions (San Francisco, USA)
Masahiro Okouchi, Naotsuka Okayama, Takashi Joh. GLP-1 analogs prevent Alzheimer’s disease in patients with type 2 diabetes.
2013.6/22-25 The American Diabetes Association 73nd Scientific Sessions (Chicago, USA)
Masahiro Okouchi, Naotsuka Okayama, Takashi Joh. GLP-1 analogs represent a novel treatment strategy for Alzheimer’s disease in patients with type 2 diabetes.
2012.6/8-12 The American Diabetes Association 72nd Scientific Sessions (Philadelphia, USA)
Masahiro Okouchi, Naotsuka Okayama, Goji Shigeki, Tadashi Iwama, Tetsuya Katsuno, Kaoru Asada, Kohei Hattori, Akitomo Goto, Yasutaka Kamiya, Tsuneo Ohno, Takashi Joh. GLP-1 analogs represents a promising treatment strategy for diabetic encephalopathy.
2012.6/8-12 The American Diabetes Association 72nd Scientific Sessions (San Diego, USA)
Masahiro Okouchi, Naotsuka Okayama, Goji Shigeki, Tadashi Iwama, Tetsuya Katsuno, Kaoru Asada, Kohei Hattori, Akitomo Goto, Yasutaka Kamiya, Tsuneo Ohno, Takashi Joh. Metformin represents a promising treatment modality for diabetic encephalopathy.
2012.6/10The American Diabetes Association 72nd Scientific Sessions (Philadelphia, USA).
Takeda Young Investigators' Fireside Discussion in ADA 2012
Masahiro Okouchi. GLP-1受容体作動薬、経鼻インスリンによる糖尿病性認知症の抑制効果
2011.6/24-28 The American Diabetes Association 71nd Scientific Sessions (San Diego, USA)
Masahiro Okouchi, Naotsuka Okayama, Ryosuke Kimura, Goji Shigeki, Yasuhiro Tamura, Kaoru Asada, Kohei Hattori, Akitomo Goto, Yasutaka Kamiya, Tsuneo Ohno, Takashi Joh. GLP-1 represents a promising treatment modality for glycemic fluctuation-induced diabetic encephalopathy.
2011.6/24-28 The American Diabetes Association 71nd Scientific Sessions (San Diego, USA)
Masahiro Okouchi, Naotsuka Okayama, Ryosuke Kimura, Goji Shigeki, Yasuhiro Tamura, Kaoru Asada, Kohei Hattori, Akitomo Goto, Yasutaka Kamiya, Tsuneo Ohno, Takashi Joh. GLP-1, insulin, or thiazolidinediones afford neuroprotection in diabetic encephalopathy through different anti-apoptotic pathways
2011.6/27 The American Diabetes Association 71nd Scientific Sessions (San Diego, USA).
Takeda Young Investigators' Fireside Discussion in ADA 2011
Masahiro Okouchi. 食後高血糖による糖尿病性認知症の発症機序、 および、GLP-1の脳神経細胞保護・再生効果について
2010.6/25-29 The American Diabetes Association 70nd Scientific Sessions (Oral Presentation, Young Investigator Award受賞) (Orlando, USA)
Masahiro Okouchi, Naotsuka Okayama, Ryosuke Kimura, Goji Shigeki, Yasuhiro Tamura, Kohei Hattori, Akitomo Goto, Yasutaka Kamiya, Tsuneo Ohno, Takashi Joh.
GLP-1 and insulin represent a promising treatment modality for diabetic encephalopathy
2010.6/25-29 The American Diabetes Association 70nd Scientific Sessions (Orlando, USA)
Masahiro Okouchi, Naotsuka Okayama, Ryosuke Kimura, Goji Shigeki, Yasuhiro Tamura, Kohei Hattori, Akitomo Goto, Yasutaka Kamiya, Tsuneo Ohno, Takashi Joh. Differential mechanisms of GLP-1, thiazolidinediones and biguanides against oxidative stress-induced neuronal cell apoptosis
2009.6/5-9 The American Diabetes Association 69nd Scientific Sessions (New Orleans, USA)
Masahiro Okouchi, Naotsuka Okayama, Yoshihiro Kondo, Yasuhiro Tamura, Yukimasa Kato, Akitomo Goto, Yasutaka Kamiya, Tsuneo Ohno, Takashi Joh. Glucose fluctuation further exacerbates neuronal cell apoptosis than sustained chronic hyperglycemia: The involvement of postprandial plasma glucose excursion in diabetic encephalopathy.
2009.6/5-9 The American Diabetes Association 69nd Scientific Sessions (New Orleans, USA)
Masahiro Okouchi, Naotsuka Okayama, Yoshihiro Kondo, Yasuhiro Tamura, Yukimasa Kato, Akitomo Goto, Yasutaka Kamiya, Tsuneo Ohno, Takashi Joh. Differential mechanisms of thiazolidinediones and biguanides against oxidative stress-induced neuronal cell apoptosis: New treatment strategy for diabetic encephalopathy
2008.6/6-10 The American Diabetes Association 68nd Scientific Sessions (San Francisco, USA)
Masahiro Okouchi, Ryosuke Kimura, Naotsuka Okayama, Yoshihiro Kondo, Ryuta Masui, Yukimasa Kato, Akitomo Goto, Yasutaka Kamiya, Tsuneo Ohno, Takashi Joh. Differential mechanisms of insulin and GLP-1 against oxidative stress-induced neuronal cell apoptosis
2008.6/6-10 The American Diabetes Association 68nd Scientific Sessions (San Francisco, USA)
Masahiro Okouchi, Ryosuke Kimura, Naotsuka Okayama, Yoshihiro Kondo, Ryuta Masui, Yukimasa Kato, Akitomo Goto, Yasutaka Kamiya, Tsuneo Ohno, Takashi Joh. In vivo and in vitro analysis of diabetic encephalopathy
2007.6/22-26 The American Diabetes Association 67nd Scientific Sessions (Chicago, USA)
Masahiro Okouchi, Naotsuka Okayama, Ryosuke Kimura, Tatsuo Mizuno, Kazuko Wakami, Kazuhiro Yamada, Kenro Imaeda, Yoshinobu Kamiya, Takashi Joh. Insulin confers neuroprotection against hyperglycemic stress-induced apoptosis through PI3K/Akt/mTOR/Nrf2/GCL/redox signaling.
2007.6/22-26 The American Diabetes Association 67nd Scientific Sessions (Chicago, USA)
Masahiro Okouchi, Naotsuka Okayama, Ryosuke Kimura, Tatsuo Mizuno, Kazuko Wakami, Kazuhiro Yamada, Kenro Imaeda, Yoshinobu Kamiya, Takashi Joh. Insulin confers neuroprotection against hyperglycemic stress-induced apoptosis through PI3K/Akt/mTOR/Nrf2/GCL/redox signaling. Insulin protection against carbonyl and hyperglycemic stress-induced neuronal cell apoptosis
2006.6/9-13 The American Diabetes Association 66nd Scientific Sessions (Oral Presentation) (Washington D.C. USA)
Masahiro Okouchi, Naotsuka Okayama, Tak Yee Aw. Insulin confers cytoprotection of human brain endothelial cells against carbonyl and glycemic stress-induced apoptosis through improvement of cellular redox status via PI3K/Akt/mTOR/Nrf2/γ-GCL signaling.
2006.6/9-13 The American Diabetes Association 66nd Scientific Sessions (Washington D.C. USA)
Masahiro Okouchi, Naotsuka Okayama, Tak Yee Aw. Insulin-induced Akt/mTOR/Nrf2/g-GCL-c signaling and restoration of cellular redox balance protects against chronic high glucose-mediated human brain endothelial cell apoptosis.
2006.6/9-13 The American Diabetes Association 66nd Scientific Sessions (Washington D.C. USA)
Masahiro Okouchi, Naotsuka Okayama, Tak Yee Aw. Biguanides and AICAR protects against carbonyl stress-induced human brain endothelial cell apoptosis through preservation of the mitochondrial membrane potential.
2006.9/9-10 The 8th Insulin Action Symposium (Shiga, Japan)
Masahiro Okouchi, Naotsuka Okayama, Tak Yee Aw. Insulin-induced Akt/mTOR/Nrf2/g-GCL-c signaling and restoration of cellular redox balance protects against chronic high glucose-mediated human brain endothelial cell apoptosis.
2005.6/10-14 The American Diabetes Association 65nd Scientific Sessions (San Diego, USA)
Masahiro Okouchi, Naotsuka Okayama, Tak Yee Aw. Human brain endothelial cells are susceptible to carbonyl stress-induced apoptosis under high glucose and reduced glucose availability, and iInsulin protects against the damage via phosphatidylinositol-3 kinase pathway.
2005.6/10-14 The American Diabetes Association 65nd Scientific Sessions (San Diego, USA)
Masahiro Okouchi, Naotsuka Okayama, Tak Yee Aw. Differential susceptibility of brain and pancreatic endothelial cells to carbonyl stress-induced apoptosis: Involvement of cellular redox and influence of high glucose and reduced glucose availability.
2005.6/10-14 The American Diabetes Association 65nd Scientific Sessions (San Diego, USA)
Masahiro Okouchi, Naotsuka Okayama, Tak Yee Aw. Hyperglycemia potentiates carbonyl stress-induced PC-12 cell apoptosis: Relationship to cellular redox and activator protease factor-1 expression
2004.6/4-8 The American Diabetes Association 64nd Scientific Sessions (Orlando, USA)
Masahiro Okouchi, Naotsuka Okayama, Makoto Itoh. High leptin concentrations exacerbate neutrophil-transendothelial migration through increasing endothelial surface expression of PECAM-1 via activation of MAP kinase
2004.6/4-8 The American Diabetes Association 64nd Scientific Sessions (Orlando, USA)
Masahiro Okouchi, Naotsuka Okayama, Tak Yee Aw. Differential susceptibility of naïve and differentiated PC-12 cells to Advanced Glycated Endproducts (AGEs): Relationship to cellular redox.
2003.6 The American Diabetes Association 63nd Scientific Sessions (New Orleans, USA)
Masahiro Okouchi, Naotsuka Okayama, Kenro Imaeda, Hitoshi Omi, Takashi Kato, Seiji Imai, Masaya Akao, Hiroaki Uranishi, Yoshiyuki Takeuchi, and Makoto Itoh. Protective actions of pioglitazone and gliclazide on neutrophil transendothelial migration and endothelial surface expression of platelet endothelial cell adhesion molecule-1 enhanced by high insulin.
2002.6/16 The American Diabetes Association 62nd Scientific Sessions (San Francisco, USA)
Masahiro Okouchi, Naotsuka Okayama, Hitoshi Omi, Kenro Imaeda, Takashi Kato, Seiji Imai, Masaya Akao, Hiroaki Uranishi, Manabu Shimizu, Makoto Itoh. Protective actions of statins on the enhanced endothelial-neutrophil adhesion and endothelial surface expression of intercellular adhesion molecule-1 mediated by high insulin.
2002.6/16 The American Diabetes Association 62nd Scientific Sessions (San Francisco, USA)
Masahiro Okouchi, Naotsuka Okayama, Hitoshi Omi, Kenro Imaeda, Takashi Kato, Seiji Imai, Masaya Akao, Hiroaki Uranishi, Manabu Shimizu, Makoto Itoh. High insulin exacerbates neutrophils transendothelial migration via a mitogen activated protein kinase activation as the direct cause of diabetic wound healing disorders.
2001.6/23 The American Diabetes Association 61st Scientific Sessions (Philadelphia, USA)
Masahiro Okouchi, Naotsuka Okayama, Hitoshi Omi, Takashi Kato, Masaya Akao, Hiroaki Uranishi, Manabu Shimizu, Makoto Itoh. Protective actions of pioglitazone and gliclazide on endothelial-neutrophil adherence and endothelial surface expression of ICAM-1 mediated by high concentrations of insulin.
2001.6/23 The American Diabetes Association 61st Scientific Sessions (Philadelphia, USA)
Masahiro Okouchi, Naotsuka Okayama, Hitoshi Omi, Takashi Kato, Masaya Akao, Hiroaki Uranishi, Manabu Shimizu, Makoto Itoh. High concentrations of insulin exacerbate endothelial-neutrophil adherence through increasing endothelial surface expression of ICAM-1 via activation of protein kinase C and MAP kinase.
